USP7: Novel Drug Target in Cancer Therapy

USP7: Novel Drug Target in Cancer Therapy

Blog Article

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that erases ubiquitin and protects substrate protein from degradation.Full activity of USP7 requires 2649-20 the C-terminal Ub-like domains fold back onto the catalytic domain, allowing the remodeling of the active site to a catalytically competent state by the C-terminal peptide.Until now, numerous proteins have been identified as substrates of USP7, which play a key role in cell cycle, DNA repair, chromatin remodeling, and epigenetic regulation.Aberrant activation or overexpression of USP7 may promote oncogenesis and viral disease, making it a target for therapeutic intervention.Currently, several synthetic small molecules dark as knight horse supplement have been identified as inhibitors of USP7, and applied in the treatment of diverse diseases.

Hence, USP7 may be a promising therapeutic target for the treatment of cancer.